MolNFT v1 · #153747 · protein

Angiotensin II type 2 receptor with ligand

6JOD · Type-2 angiotensin II receptor: “Angiotensin II type 2 receptor with ligand”. X-ray diffraction, 11 pockets (best druggability 0.75). MolNFT v1 #153747 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6JOD
Type: protein
Length: 805 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Type-2 angiotensin II receptor; Angiotensin II; Soluble cytochrome B562,SOLUBLE…
UniProt: P50052, P0ABE7
Pockets: 11 · best druggability 0.75

Structure

x-ray diffraction · 5 distinct chains · 38% helix, 30% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Type-2 angiotensin II receptor	protein	306	77% helix, 4% strand	P50052
B	Angiotensin II	protein	8	0% helix, 0% strand	—
C	Soluble cytochrome B562,SOLUBLE cytochrome B562	protein	59	83% helix, 0% strand	P0ABE7
H	Heavy chain of 4A03FAB	protein	220	1% helix, 52% strand	—
L	Light chain of 4A03FAB	protein	212	6% helix, 53% strand	—

Pockets

11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	946	0.75	0.78	74	empty
2	443	0.67	0.79	43	empty
3	508	0.59	0.74	40	empty
4	191	0.48	0.75	29	empty
5	164	0.46	0.76	26	empty

Interfaces

6 interfaces between chains.

H–L · 1859 Å² buried · 14 hydrogen bonds · protein-protein
A–B · 832 Å² buried · 10 hydrogen bonds · protein-protein
A–H · 776 Å² buried · 12 hydrogen bonds · protein-protein
A–L · 344 Å² buried · 5 hydrogen bonds · protein-protein
C–L · 230 Å² buried · 1 hydrogen bond · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

6JOD · Angiotensin II type 2 receptor with ligand · the same entry in another collection · chain B against B, TM-score 1.00
P50052 · AlphaFold monomer V2.0 prediction for type-2 angiotensin II receptor (P50052) · a predicted model of the same protein · chain A against A, TM-score 0.98
P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain C against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P50052
Every structure of UniProt P0ABE7
Elsewhere: RCSB PDB 6JOD · PDBe 6JOD · UniProt P50052 · UniProt P0ABE7

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