MolNFT v1 · #153634 · protein
Crystal structure of human SPSB2 in the apo-state
6JKJ · Spry domain-containing socs box protein 2: “Crystal structure of human SPSB2 in the apo-state”. X-ray diffraction, 2 pockets (best druggability 0.31). MolNFT v1 #153634 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6JKJ
- Type
- protein
- Length
- 394 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Spry domain-containing socs box protein 2
- UniProt
- Q99619
- Pockets
- 2 · best druggability 0.31
Structure
x-ray diffraction · 2 distinct chains · 10% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Spry domain-containing socs box protein 2 | protein | 195 | 11% helix, 42% strand | Q99619 |
| B | Spry domain-containing socs box protein 2 | protein | 199 | 9% helix, 41% strand | Q99619 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 56 | 0.31 | 0.76 | 16 | empty |
| 2 | 57 | 0.27 | 0.74 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 331 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6JKJ · Crystal structure of human SPSB2 in the apo-state · the same entry in another collection · chain A against A, TM-score 1.00
- Q99619 · AlphaFold monomer V2.0 prediction for spry domain-containing socs box protein 2 (Q99619) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99619
- Elsewhere: RCSB PDB 6JKJ · PDBe 6JKJ · UniProt Q99619
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