UniProt Q99619
SPRY domain-containing SOCS box protein 2 (Q99619)
SPRY domain-containing SOCS box protein 2 (UniProt Q99619): 15 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 6 pockets. Binding sites, druggability and experiment against prediction (TM-score) in…
- UniProt
- Q99619
- Protein
- SPRY domain-containing SOCS box protein 2
- Experimental structures
- 15
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 6 · 1 record with a druggable one
Structures
16 records of Q99619 in the MolNFT archive: 15 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 3EMW | Crystal Structure of human splA/ryanodine receptor domain and SOCS box containing 2 (SPSB2) in… | x-ray diffraction | A | — | — |
| 3EMW | Crystal structure of human SPLA/RYANODINE receptor domain and socs box containing 2 (SPSB2) in… | x-ray diffraction | A | — | — |
| 5XN3 | Crystal structure of SPSB2 in complex with a rational designed rgd containing cyclic peptide… | x-ray diffraction | A | — | — |
| 6DN5 | SPRY domain-containing SOCS box protein 2 complexed with WDINNN(BAL) cyclic peptide inhibitor | x-ray diffraction | A | SO4 | 1 (best 0.38) |
| 6DN5 | Spry domain-containing socs box protein 2 complexed with WDINNN(BAL) cyclic peptide inhibitor | x-ray diffraction | A | SO4 | — |
| 6DN6 | SPRY domain-containing SOCS box protein 2 complexed with INNN(ABU) cyclic peptide inhibitor | x-ray diffraction | A | — | — |
| 6DN6 | Spry domain-containing socs box protein 2 complexed with INNN(ABU) cyclic peptide inhibitor | x-ray diffraction | A | — | — |
| 6JKJ | Crystal structure of human SPSB2 in the apo-state | x-ray diffraction | A, B | — | 2 (best 0.31) |
| 6JKJ | Crystal structure of human SPSB2 in the apo-state | x-ray diffraction | A, B | — | — |
| 6JWM | Crystal structure of the SPRY domain of SPSB2 in complex with cR7, a potent cyclic peptide… | x-ray diffraction | A | — | — |
| 6JWM | Crystal structure of the spry domain of SPSB2 in complex with CR7, a potent cyclic peptide… | x-ray diffraction | A | — | — |
| 6JWN | Crystal structure of the SPRY domain of SPSB2 in complex with cR9, a cyclic peptide inhibitor of… | x-ray diffraction | A, C | — | 2 (best 0.66) |
| 6JWN | Crystal structure of the spry domain of SPSB2 in complex with CR9, a cyclic peptide inhibitor of… | x-ray diffraction | A, C | — | — |
| 6KEY | Structural basis for the regulation of inducible nitric oxide synthase (iNOS) by the SPRY… | x-ray diffraction | A | — | — |
| 6KEY | Structural basis for the regulation of inducible nitric oxide synthase (inos) by the spry… | x-ray diffraction | A | — | — |
| Q99619 | AlphaFold monomer V2.0 prediction for spry domain-containing socs box protein 2 (Q99619) | predicted | A | — | 1 (best 0.32) |
Ligands
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 6DN5 chain A against the predicted model Q99619: TM-score 0.98, RMSD 0.86 Å
- 6DN5 chain A against the predicted model Q99619: TM-score 0.98, RMSD 0.86 Å
- 6JKJ chain A against the predicted model Q99619: TM-score 0.98, RMSD 0.96 Å
- 6JKJ chain A against the predicted model Q99619: TM-score 0.98, RMSD 0.96 Å
- 6JWN chain A against the predicted model Q99619: TM-score 0.98, RMSD 0.96 Å
- 6JWN chain A against the predicted model Q99619: TM-score 0.98, RMSD 0.96 Å
- 5XN3 chain A against the predicted model Q99619: TM-score 0.97, RMSD 1.09 Å
- 3EMW chain A against the predicted model Q99619: TM-score 0.97, RMSD 1.21 Å
- 3EMW chain A against the predicted model Q99619: TM-score 0.97, RMSD 1.21 Å
- 6KEY chain A against the predicted model Q99619: TM-score 0.97, RMSD 1.36 Å
Elsewhere
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