MolNFT v1 · #146627 · protein

Spry domain-containing socs box protein 2 complexed with INNN(ABU) cyclic peptide inhibitor

6DN6: “Spry domain-containing socs box protein 2 complexed with INNN(ABU) cyclic peptide inhibitor”. X-ray diffraction, 1 ligand (ABU). MolNFT v1 #146627 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6DN6
Type: protein
Length: 198 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spry domain-containing socs box protein 2; INNN(ABU) cyclic peptide inhibitor
UniProt: Q99619
Ligands: ABU

Structure

x-ray diffraction · 2 distinct chains · 11% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Spry domain-containing socs box protein 2	protein	194	11% helix, 41% strand	Q99619
B	INNN(ABU) cyclic peptide inhibitor	protein	4	0% helix, 0% strand	—

Ligands and binding sites

ABU · Gamma-amino-butanoic acid · ligand · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

A–B · 297 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent (covalent ligand).

Compared structures

6DN6 · SPRY domain-containing SOCS box protein 2 complexed with INNN(ABU) cyclic peptide… · the same entry in another collection · chain A against A, TM-score 1.00
Q99619 · AlphaFold monomer V2.0 prediction for spry domain-containing socs box protein 2 (Q99619) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99619
Elsewhere: RCSB PDB 6DN6 · PDBe 6DN6 · UniProt Q99619

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.