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Crystal structure of human SPSB2 in the apo-state

Analyse Crystal structure of human SPSB2 in the apo-state in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6JKJ
Type: protein
Length: 394 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Spry domain-containing socs box protein 2
UniProt: Q99619
Pockets: 2 · best druggability 0.31

Structure

x-ray diffraction · 2 distinct chains · 10% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Spry domain-containing socs box protein 2	protein	195	11% helix, 42% strand	Q99619
B	Spry domain-containing socs box protein 2	protein	199	9% helix, 41% strand	Q99619

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.31	0.76	16	empty
2	57	0.27	0.74	20	empty

Interfaces

1 interface between chains.

A–B · 331 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

6JKJ · Crystal structure of human SPSB2 in the apo-state · the same entry in another collection · chain A against A, TM-score 1.00
Q99619 · AlphaFold monomer V2.0 prediction for spry domain-containing socs box protein 2 (Q99619) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99619
Elsewhere: RCSB PDB 6JKJ · PDBe 6JKJ · UniProt Q99619

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