MolNFT v1 · #153475 · protein
GDP bound MITOFUSIN2 (MFN2)
6JFK · Mitofusin-2,CDNA FLJ57997, highly similar to transmembrane…: “GDP bound MITOFUSIN2 (MFN2)”. X-ray diffraction, 1 ligand (GDP), 2 pockets (best druggability 0.57). MolNFT v1 #153475 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6JFK
- Type
- protein
- Length
- 428 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitofusin-2,CDNA FLJ57997, highly similar to transmembrane GTPase MFN2
- EC
- 3.6.5.-
- UniProt
- O95140, B7Z3H8
- Ligands
- GDP
- Pockets
- 2 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 60% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitofusin-2,CDNA FLJ57997, highly similar to transmembrane GTPase MFN2 (EC 3.6.5.-) | protein | 428 | 60% helix, 11% strand | O95140, B7Z3H8 |
Ligands and binding sites
- GDP · Guanosine-5'-diphosphate · ligand · chains A
- GOL · Glycerol · additive · 4 copies · chains A
- CIT · Citric acid · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 211 | 0.57 | 0.80 | 36 | GDP |
| 2 | 152 | 0.43 | 0.75 | 28 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95140
- Every structure of UniProt B7Z3H8
- Elsewhere: RCSB PDB 6JFK · PDBe 6JFK · UniProt O95140 · UniProt B7Z3H8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.