MolNFT v1 · #153378 · protein
Complex structure of axin-dix and DVL2-dix
6JCK · Axin-1: “Complex structure of axin-dix and DVL2-dix”. X-ray diffraction, 1 pocket (best druggability 0.35). MolNFT v1 #153378 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6JCK
- Type
- protein
- Length
- 145 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Axin-1; Segment polarity protein dishevelled homolog dvl-2
- UniProt
- O15169, O14641
- Pockets
- 1 · best druggability 0.35
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Axin-1 | protein | 79 | 6% helix, 41% strand | O15169 |
| B | Segment polarity protein dishevelled homolog dvl-2 | protein | 66 | 12% helix, 41% strand | O14641 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 66 | 0.35 | 0.77 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 657 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6JCK · Complex structure of Axin-DIX and Dvl2-DIX · the same entry in another collection · chain A against A, TM-score 1.00
- O14641 · AlphaFold monomer V2.0 prediction for segment polarity protein dishevelled homolog dvl-2… · a predicted model of the same protein · chain B against A, TM-score 0.95
- O15169 · AlphaFold monomer V2.0 prediction for axin-1 (O15169) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15169
- Every structure of UniProt O14641
- Elsewhere: RCSB PDB 6JCK · PDBe 6JCK · UniProt O15169 · UniProt O14641
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