UniProt O14641
Segment polarity protein dishevelled homolog DVL-2 (O14641)
Segment polarity protein dishevelled homolog DVL-2 (UniProt O14641): 24 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 13 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- O14641
- Protein
- Segment polarity protein dishevelled homolog DVL-2
- Experimental structures
- 24
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 13 · 4 records with a druggable one
Structures
25 records of O14641 in the MolNFT archive: 24 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2REY | Crystal structure of the PDZ domain of human dishevelled 2 (homologous to Drosophila dsh) | x-ray diffraction | A | — | — |
| 2REY | Crystal structure of the PDZ domain of human dishevelled 2 (homologous to drosophila dsh) | x-ray diffraction | A | — | — |
| 3CBX | The Dvl2 PDZ Domain in Complex with the C1 Inhibitory Peptide | x-ray diffraction | A, B | — | — |
| 3CBX | The DVL2 PDZ domain in complex with the C1 inhibitory peptide | x-ray diffraction | A, B | — | — |
| 3CBY | The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide | x-ray diffraction | A, B | — | — |
| 3CBY | The DVL2 PDZ domain in complex with the N1 inhibitory peptide | x-ray diffraction | A, B | — | — |
| 3CBZ | The Dvl2 PDZ Domain in Complex with the N2 Inhibitory Peptide | x-ray diffraction | A | — | — |
| 3CBZ | The DVL2 PDZ domain in complex with the N2 inhibitory peptide | x-ray diffraction | A | — | — |
| 3CC0 | The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide | x-ray diffraction | A, B, C | — | — |
| 3CC0 | The DVL2 PDZ domain in complex with the N3 inhibitory peptide | x-ray diffraction | A, B, C | — | — |
| 4WIP | DIX domain of human Dvl2 | x-ray diffraction | A, B, C | — | — |
| 4WIP | Dix domain of human DVL2 | x-ray diffraction | A, B, C | — | — |
| 5LNP | Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal form crystallised from… | x-ray diffraction | A, B, C, D | SO4 | 2 (best 0.75) |
| 5LNP | Domain-swapped dimer of human DISHEVELLED2 dep domain: monoclinic crystal form crystallised from… | x-ray diffraction | A, B, C, D | SO4 | — |
| 5SUY | Domain-swapped dimer of human Dishevelled2 DEP domain: monoclinic crystal form crystallised from… | x-ray diffraction | A, B, C, D | SO4 | 3 (best 0.75) |
| 5SUY | Domain-swapped dimer of human DISHEVELLED2 dep domain: monoclinic crystal form crystallised from… | x-ray diffraction | A, B, C, D | SO4 | — |
| 5SUZ | Domain-swapped dimer of human Dishevelled2 DEP domain: C-centered monoclinic crystal form… | x-ray diffraction | A, B | — | — |
| 5SUZ | Domain-swapped dimer of human DISHEVELLED2 dep domain: C-centered monoclinic crystal form… | x-ray diffraction | A, B | — | — |
| 6IW3 | High resolution structure of Dvl2-DIX Y27W/C80S mutant | x-ray diffraction | A | — | — |
| 6IW3 | High resolution structure of DVL2-dix Y27W/C80S mutant | x-ray diffraction | A | — | — |
| 6JCK | Complex structure of axin-dix and DVL2-dix | x-ray diffraction | B | — | — |
| 8WM9 | Fzd4/DEP complex | electron microscopy | C | — | 4 (best 0.60) |
| 8WMA | Fzd4/DEP complex (local refined) | electron microscopy | C | — | 3 (best 0.62) |
| 8WWR | Crystal structure of apo human dishevelled 2 (Dvl2) PDZ domain | x-ray diffraction | A | — | 1 (best 0.33) |
| O14641 | AlphaFold monomer V2.0 prediction for segment polarity protein dishevelled homolog dvl-2 (O14641) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 4 records
Experiment against prediction
- 6IW3 chain A against the predicted model O14641: TM-score 0.96, RMSD 0.78 Å
- 6IW3 chain A against the predicted model O14641: TM-score 0.96, RMSD 0.78 Å
- 4WIP chain A against the predicted model O14641: TM-score 0.96, RMSD 0.83 Å
- 4WIP chain A against the predicted model O14641: TM-score 0.96, RMSD 0.83 Å
- 4WIP chain C against the predicted model O14641: TM-score 0.96, RMSD 0.78 Å
- 4WIP chain C against the predicted model O14641: TM-score 0.96, RMSD 0.78 Å
- 4WIP chain B against the predicted model O14641: TM-score 0.95, RMSD 0.94 Å
- 4WIP chain B against the predicted model O14641: TM-score 0.95, RMSD 0.94 Å
- 6JCK chain B against the predicted model O14641: TM-score 0.95, RMSD 0.64 Å
- 8WMA chain C against the predicted model O14641: TM-score 0.91, RMSD 1.12 Å
Elsewhere
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