Structural basis of tubulin detyrosination by vasohibins-svbp enzyme complex and functional implications

Structure

x-ray diffraction · 2 distinct chains · 47% helix, 18% strand (DSSP).

Ligands and binding sites

• BJL · N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-tyrosine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 1368 Ų buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (covalent ligand).

Compared structures

• 6J4P · Structural basis of tubulin detyrosination by vasohibins-SVBP enzyme complex and… · the same entry in another collection · chain A against A, TM-score 1.00
• Q86V25 · AlphaFold monomer V2.0 prediction for tubulinyl-tyr carboxypeptidase 2 (Q86V25) · a predicted model of the same protein · chain A against A, TM-score 0.99
• Q8N300 · AlphaFold monomer V2.0 prediction for small vasohibin-binding protein (Q8N300) · a predicted model of the same protein · chain B against A, TM-score 0.79

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q86V25
• Every structure of UniProt Q8N300
• Elsewhere: RCSB PDB 6J4P · PDBe 6J4P · UniProt Q86V25 · UniProt Q8N300