MolNFT v1 · #152813 · protein
Crystal structure of importin-ALPHA1 bound to the 53BP1 nuclear localization signal (S1678D)
6IUA · Importin subunit alpha-1: “Crystal structure of importin-ALPHA1 bound to the 53BP1 nuclear localization signal (S1678D)”. X-ray diffraction, 2 pockets (best druggability 0.62). MolNFT v1 #152813 on GenesisL1: 3D structure, binding…
- PDB
- 6IUA
- Type
- protein
- Length
- 444 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin subunit alpha-1; Peptide from TP53-binding protein 1
- UniProt
- P52293, Q12888
- Pockets
- 2 · best druggability 0.62
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Importin subunit alpha-1 | protein | 422 | 75% helix, 0% strand | P52293 |
| B | Peptide from TP53-binding protein 1 | protein | 22 | 0% helix, 0% strand | Q12888 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 381 | 0.62 | 0.78 | 47 | empty |
| 2 | 68 | 0.45 | 0.82 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1244 Ų buried · 29 hydrogen bonds · protein-protein
Compared structures
- 6IUA · Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal… · the same entry in another collection · chain A against A, TM-score 1.00
- Q12888 · AlphaFold monomer V2.0 prediction for TP53-binding protein 1 (Q12888) · a predicted model of the same protein · chain B against A, TM-score 0.26
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P52293
- Every structure of UniProt Q12888
- Elsewhere: RCSB PDB 6IUA · PDBe 6IUA · UniProt P52293 · UniProt Q12888
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