UniProt Q12888
TP53-binding protein 1 (Q12888)
TP53-binding protein 1 (UniProt Q12888): 56 experimental structures on GenesisL1, 9 ligands bound, 28 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- Q12888
- Protein
- TP53-binding protein 1
- Experimental structures
- 56
- Predicted models
- 0
- Ligands
- 9
- Pockets
- 28 · 6 records with a druggable one
Structures
56 records of Q12888 in the MolNFT archive: 56 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1GZH | Crystal structure of the BRCT domains of human 53BP1 bound to the p53 tumor supressor | x-ray diffraction | B, D | — | — |
| 1GZH | Crystal structure of the brct domains of human 53BP1 bound to the P53 tumor supressor | x-ray diffraction | B, D | — | — |
| 1KZY | Crystal Structure of the 53bp1 BRCT Region Complexed to Tumor Suppressor P53 | x-ray diffraction | C, D | — | — |
| 1KZY | Crystal structure of the 53BP1 brct region complexed to tumor suppressor P53 | x-ray diffraction | C, D | — | — |
| 1XNI | Tandem Tudor Domain of 53BP1 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 1XNI | Tandem tudor domain of 53BP1 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | — | — |
| 2G3R | Crystal Structure of 53BP1 tandem tudor domains at 1.2 A resolution | x-ray diffraction | A | — | — |
| 2G3R | Crystal structure of 53BP1 tandem tudor domains at 1.2 a resolution | x-ray diffraction | A | — | — |
| 2IG0 | Structure of 53BP1/methylated histone peptide complex | x-ray diffraction | A | — | — |
| 2IG0 | Structure of 53BP1/METHYLATED histone peptide complex | x-ray diffraction | A | — | — |
| 2LVM | Solution structure of human 53BP1 tandem Tudor domains in complex with a histone H4K20me2 peptide | solution nmr | A | — | — |
| 2LVM | Solution structure of human 53BP1 tandem tudor domains in complex with a histone H4K20ME2 peptide | solution nmr | A | — | — |
| 2MWO | Solution structure of 53BP1 tandem Tudor domains in complex with a p53K370me2 peptide | solution nmr | A | — | — |
| 2MWO | Solution structure of 53BP1 tandem tudor domains in complex with a P53K370ME2 peptide | solution nmr | A | — | — |
| 2MWP | Solution structure of 53BP1 tandem Tudor domains in complex with a p53K382me2 peptide | solution nmr | A | — | — |
| 2MWP | Solution structure of 53BP1 tandem tudor domains in complex with a P53K382ME2 peptide | solution nmr | A | — | — |
| 3LGF | Crystal structure of the 53BP1 tandem tudor domain in complex with p53K370me2 | x-ray diffraction | A | — | — |
| 3LGF | Crystal structure of the 53BP1 tandem tudor domain in complex with P53K370ME2 | x-ray diffraction | A | — | — |
| 3LGL | Crystal structure of the 53BP1 tandem tudor domain in complex with p53K382me2 | x-ray diffraction | A | — | — |
| 3LGL | Crystal structure of the 53BP1 tandem tudor domain in complex with P53K382ME2 | x-ray diffraction | A | — | — |
| 3LH0 | Crystal structure of the 53BP1 tandem tudor domain in complex with p53K372me2 | x-ray diffraction | A | — | — |
| 3LH0 | Crystal structure of the 53BP1 tandem tudor domain in complex with P53K372ME2 | x-ray diffraction | A | — | — |
| 4CRI | Crystal Structure of 53BP1 tandem tudor domains in complex with methylated K810 Rb peptide | x-ray diffraction | A, B | — | — |
| 4CRI | Crystal structure of 53BP1 tandem tudor domains in complex with methylated K810 rb peptide | x-ray diffraction | A, B | — | — |
| 4RG2 | Tudor Domain of Tumor suppressor p53BP1 with small molecule ligand | x-ray diffraction | A, B | — | — |
| 4RG2 | Tudor domain of tumor suppressor P53BP1 with small molecule ligand | x-ray diffraction | A, B | — | — |
| 4X34 | Crystal structure of the 53BP1 tandem tudor domain in complex with p53K381acK382me2 | x-ray diffraction | A, B | — | — |
| 4X34 | Crystal structure of the 53BP1 tandem tudor domain in complex with P53K381ACK382ME2 | x-ray diffraction | A, B | — | — |
| 5ECG | Crystal structure of the BRCT domains of 53BP1 in complex with p53 and H2AX-pSer139 (gammaH2AX) | x-ray diffraction | C, D | — | — |
| 5ECG | Crystal structure of the brct domains of 53BP1 in complex with P53 and H2AX-PSER139 (GAMMAH2AX) | x-ray diffraction | C, D | — | — |
| 5J26 | Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant | x-ray diffraction | A | — | — |
| 5J26 | Crystal structure of a 53BP1 tudor domain in complex with a ubiquitin variant | x-ray diffraction | A | — | — |
| 5Z78 | Structure of TIRR/53BP1 complex | x-ray diffraction | C | — | — |
| 5ZCJ | Crystal structure of complex | x-ray diffraction | C | — | — |
| 5ZCJ | Crystal structure of complex | x-ray diffraction | C | — | — |
| 6CO1 | Structure of human tirr in complex with 53BP1 tudor domains | x-ray diffraction | E, F | — | — |
| 6CO2 | Structure of an engineered protein (NUDT16TI) in complex with 53BP1 Tudor domains | x-ray diffraction | C, D | — | 3 (best 0.71) |
| 6CO2 | Structure of an engineered protein (NUDT16TI) in complex with 53BP1 tudor domains | x-ray diffraction | C, D | — | — |
| 6IU7 | Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (wild-type) | x-ray diffraction | B | — | — |
| 6IU7 | Crystal structure of importin-ALPHA1 bound to the 53BP1 nuclear localization signal (wild-type) | x-ray diffraction | B | — | — |
| 6IUA | Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal (S1678D) | x-ray diffraction | B | — | 1 (best 0.62) |
| 6IUA | Crystal structure of importin-ALPHA1 bound to the 53BP1 nuclear localization signal (S1678D) | x-ray diffraction | B | — | — |
| 6MXX | Structure of 53BP1 tandem tudor domains in complex with small molecule UNC2991 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | PO4, K6P | — |
| 6MXY | Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC3351 | x-ray diffraction | A, B | PO4, K6M | 2 (best 0.78) |
| 6MXY | Structure of 53BP1 tandem tudor domains in complex with small molecule UNC3351 | x-ray diffraction | A, B | PO4, K6M | — |
| 6MXZ | Structure of 53BP1 Tudor domains in complex with small molecule UNC3474 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | K6S | 14 (best 0.82) |
| 6MXZ | Structure of 53BP1 tudor domains in complex with small molecule UNC3474 | x-ray diffraction | A, B, C, D, E, F, G, H, I, J | K6S | — |
| 6MY0 | Structure of 53BP1 tandem tudor domains with E1549P and D1550N mutations | x-ray diffraction | A, B | — | — |
| 6VA5 | Tudor domain of tumor suppressor P53BP1 with mfp-4184 | x-ray diffraction | A | QSS, SO4, UNX | — |
| 6VIP | Tudor domain of tumor suppressor P53BP1 with mfp-6008 | x-ray diffraction | A, B | QXY, UNX | — |
| 7LIN | X-ray structure of spop math domain (D140G) in complex with a 53BP1 peptide | x-ray diffraction | B | — | — |
| 7LIO | X-ray structure of SPOP MATH domain (S119D) in complex with a 53BP1 peptide | x-ray diffraction | C, D | — | — |
| 7LIO | X-ray structure of spop math domain (S119D) in complex with a 53BP1 peptide | x-ray diffraction | C, D | — | — |
| 8F0W | Tudor Domain of Tumor suppressor p53BP1 with MFP-5956 | x-ray diffraction | A, B | X9N, UNX | 4 (best 0.73) |
| 8HKW | Crystal structure of importin-alpha3 bound to the 53BP1 nuclear localization signal | x-ray diffraction | C, D | — | 4 (best 0.84) |
| Q12888 | AlphaFold monomer V2.0 prediction for TP53-binding protein 1 (Q12888) | — | — | — |
Ligands
- PO4 · Phosphate ion · in 3 records
- UNX · Unknown atom or ion · in 3 records
- K6M · N-[3-(tert-butylamino)propyl]-3-(trifluoromethyl) benzamide · in 2 records
- K6S · N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide · in 2 records
- K6P · N-[3-(tert-butylamino)propyl]-3-iodobenzamide · in 1 record
- QSS · 2-(4-methylpiperazin-1-yl)aniline · in 1 record
- QXY · {4-[(3,5-dimethyl-1H-pyrazol-1-yl)methyl]phenyl}(4-ethylpiperazin-1-yl)methanone · in 1 record
- SO4 · Sulfate ion · in 1 record
- X9N · 1-[4-(4-ethylpiperazin-1-yl)-3-fluorophenyl]butan-1-one · in 1 record
Elsewhere
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