MolNFT v1 · #152810 · protein

Crystal structure of importin-ALPHA1 bound to the 53BP1 nuclear localization signal (wild-type)

6IU7 · Importin subunit alpha-1: “Crystal structure of importin-ALPHA1 bound to the 53BP1 nuclear localization signal (wild-type)”. X-ray diffraction, 1 pocket (best druggability 0.46). MolNFT v1 #152810 on GenesisL1: 3D structure, binding…

PDB: 6IU7
Type: protein
Length: 444 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-1; Peptide from TP53-binding protein 1
UniProt: P52293, Q12888
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 2 distinct chains · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Importin subunit alpha-1	protein	422	75% helix, 0% strand	P52293
B	Peptide from TP53-binding protein 1	protein	22	14% helix, 0% strand	Q12888

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	78	0.46	0.81	13	empty

Interfaces

1 interface between chains.

A–B · 1393 Å² buried · 35 hydrogen bonds · protein-protein

Compared structures

6IU7 · Crystal structure of importin-alpha1 bound to the 53BP1 nuclear localization signal… · the same entry in another collection · chain A against A, TM-score 1.00
Q12888 · AlphaFold monomer V2.0 prediction for TP53-binding protein 1 (Q12888) · a predicted model of the same protein · chain B against A, TM-score 0.19

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Every structure of UniProt Q12888
Elsewhere: RCSB PDB 6IU7 · PDBe 6IU7 · UniProt P52293 · UniProt Q12888

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