MolNFT v1 · #152778 · protein
Crystal structure of LYS27-linked di-ubiquitin in complex with its selective interacting protein UCHL3
6ISU · Ubiquitin carboxyl-terminal hydrolase isozyme L3: “Crystal structure of LYS27-linked di-ubiquitin in complex with its selective interacting protein UCHL3”. X-ray diffraction, 3 pockets (best druggability 0.45). MolNFT v1 #152778 on…
- PDB
- 6ISU
- Type
- protein
- Length
- 379 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ubiquitin carboxyl-terminal hydrolase isozyme L3; Ubiquitin
- EC
- 3.4.19.12
- UniProt
- P15374, P0CG47
- Pockets
- 3 · best druggability 0.45
Structure
x-ray diffraction · 3 distinct chains · 33% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Ubiquitin carboxyl-terminal hydrolase isozyme L3 (EC 3.4.19.12) | protein | 227 | 39% helix, 20% strand | P15374 |
| B | Ubiquitin | protein | 76 | 24% helix, 33% strand | P0CG47 |
| C | Ubiquitin | protein | 76 | 24% helix, 36% strand | P0CG47 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 75 | 0.45 | 0.81 | 16 | empty |
| 2 | 95 | 0.40 | 0.76 | 20 | empty |
| 3 | 53 | 0.30 | 0.76 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1152 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 598 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 155 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (nonstandard).
Compared structures
- 6ISU · Crystal structure of Lys27-linked di-ubiquitin in complex with its selective interacting… · the same entry in another collection · chain A against A, TM-score 1.00
- P15374 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase isozyme L3… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15374
- Every structure of UniProt P0CG47
- Elsewhere: RCSB PDB 6ISU · PDBe 6ISU · UniProt P15374 · UniProt P0CG47
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