UniProt P15374
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (P15374)
Ubiquitin carboxyl-terminal hydrolase isozyme L3 (UniProt P15374), EC 3.1.2.15, 3.4.19.12: 9 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 23 pockets. Binding sites, druggability and experiment…
- UniProt
- P15374
- Protein
- Ubiquitin carboxyl-terminal hydrolase isozyme L3
- EC
- 3.1.2.15, 3.4.19.12
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 23 · 3 records with a druggable one
Structures
10 records of P15374 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1UCH | Deubiquitinating enzyme uch-L3 (human) at 1.8 ångström resolution | x-ray diffraction | A | — | — |
| 1UCH | Deubiquitinating enzyme uch-L3 (human) at 1.8 ångström resolution | x-ray diffraction | A | — | — |
| 1XD3 | Crystal structure of UCHL3-UbVME complex | x-ray diffraction | A, C | MG, GVE | 5 (best 0.63) |
| 1XD3 | Crystal structure of UCHL3-ubvme complex | x-ray diffraction | A, C | — | — |
| 6ISU | Crystal structure of Lys27-linked di-ubiquitin in complex with its selective interacting protein… | x-ray diffraction | A | — | 3 (best 0.45) |
| 6ISU | Crystal structure of LYS27-linked di-ubiquitin in complex with its selective interacting protein… | x-ray diffraction | A | — | — |
| 6QML | UCHL3 in complex with synthetic, K27-linked diubiquitin | x-ray diffraction | A, D | K, BR, CL | 12 (best 0.60) |
| 6QML | UCHL3 in complex with synthetic, K27-linked diubiquitin | x-ray diffraction | A, D | K, BR, CL | — |
| 7YV4 | Crystal structure of human UCHL3 in complex with Farrerol | x-ray diffraction | A | JXY | 2 (best 0.75) |
| P15374 | AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase isozyme L3 (P15374) | predicted | A | — | 1 (best 0.48) |
Ligands
Experiment against prediction
- 6QML chain A against the predicted model P15374: TM-score 0.99, RMSD 0.53 Å
- 6QML chain A against the predicted model P15374: TM-score 0.99, RMSD 0.53 Å
- 6ISU chain A against the predicted model P15374: TM-score 0.99, RMSD 0.53 Å
- 6ISU chain A against the predicted model P15374: TM-score 0.99, RMSD 0.53 Å
- 1XD3 chain C against the predicted model P15374: TM-score 0.99, RMSD 0.56 Å
- 1XD3 chain C against the predicted model P15374: TM-score 0.99, RMSD 0.56 Å
- 1XD3 chain A against the predicted model P15374: TM-score 0.99, RMSD 0.72 Å
- 1XD3 chain A against the predicted model P15374: TM-score 0.99, RMSD 0.72 Å
- 1UCH chain A against the predicted model P15374: TM-score 0.98, RMSD 1.10 Å
- 1UCH chain A against the predicted model P15374: TM-score 0.98, RMSD 1.10 Å
Elsewhere
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