MolNFT v1 · #151760 · protein
SERCA2A from pig heart
6HXB · SARCOPLASMIC/ENDOPLASMIC reticulum calcium ATPase 2: “SERCA2A from pig heart”. X-ray diffraction, 3 ligands (ACP, CA, K), 15 pockets (best druggability 0.84). MolNFT v1 #151760 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 6HXB
- Type
- protein
- Length
- 968 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SARCOPLASMIC/ENDOPLASMIC reticulum calcium ATPase 2
- EC
- 3.6.3.8
- UniProt
- P11607
- Ligands
- ACP, CA, K
- Pockets
- 15 · best druggability 0.84
Structure
x-ray diffraction · 1 distinct chain · 46% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SARCOPLASMIC/ENDOPLASMIC reticulum calcium ATPase 2 (EC 3.6.3.8) | protein | 968 | 46% helix, 15% strand | P11607 |
Ligands and binding sites
- ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains A
- CA · Calcium ion · metal · 3 copies · chains A
- K · Potassium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
15 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1019 | 0.84 | 0.85 | 108 | CA, ACP |
| 2 | 494 | 0.76 | 0.84 | 55 | empty |
| 3 | 189 | 0.74 | 0.90 | 29 | empty |
| 4 | 371 | 0.72 | 0.83 | 47 | empty |
| 5 | 61 | 0.69 | 0.96 | 17 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11607
- Elsewhere: RCSB PDB 6HXB · PDBe 6HXB · UniProt P11607
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