MolNFT v1 · #151503 · protein

Crystal structure of human PIF1 helicase, apoform.

6HPT · ATP-dependent DNA helicase PIF1: “Crystal structure of human PIF1 helicase, apoform.”. X-ray diffraction, 1 ligand (SO4), 6 pockets (best druggability 0.77). MolNFT v1 #151503 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 6HPT
Type: protein
Length: 416 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATP-dependent DNA helicase PIF1
EC: 3.6.4.12
UniProt: Q9H611
Ligands: SO4
Pockets: 6 · best druggability 0.77

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 22% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	ATP-dependent DNA helicase PIF1 (EC 3.6.4.12)	protein	416	37% helix, 22% strand	Q9H611

Ligands and binding sites

SO4 · Sulfate ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	645	0.77	0.83	58	SO4
2	252	0.62	0.80	22	empty
3	399	0.61	0.77	48	empty
4	123	0.41	0.76	29	empty
5	75	0.37	0.77	11	empty

Compared structures

6HPT · Crystal structure of human Pif1 helicase, apoform. · the same entry in another collection · chain A against A, TM-score 1.00
Q9H611 · AlphaFold monomer V2.0 prediction for ATP-dependent DNA helicase PIF1 (Q9H611) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9H611
Elsewhere: RCSB PDB 6HPT · PDBe 6HPT · UniProt Q9H611

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