MolNFT v1 · #151462 · protein
Structure of BECLIN1 lir motif bound to gabarap
6HOJ · Beclin-1,GAMMA-aminobutyric acid receptor-associated protein: “Structure of BECLIN1 lir motif bound to gabarap”. X-ray diffraction, 1 ligand (SO4), 4 pockets (best druggability 0.82). MolNFT v1 #151462 on GenesisL1: 3D structure…
- PDB
- 6HOJ
- Type
- protein
- Length
- 371 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Beclin-1,GAMMA-aminobutyric acid receptor-associated protein
- UniProt
- Q14457, O95166
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 30% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Beclin-1,GAMMA-aminobutyric acid receptor-associated protein | protein | 124 | 31% helix, 23% strand | Q14457, O95166 |
| B | Beclin-1,GAMMA-aminobutyric acid receptor-associated protein | protein | 123 | 29% helix, 23% strand | Q14457, O95166 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 909 | 0.82 | 0.84 | 59 | SO4 |
| 2 | 260 | 0.60 | 0.79 | 44 | empty |
| 3 | 198 | 0.50 | 0.76 | 33 | empty |
| 4 | 112 | 0.48 | 0.80 | 30 | empty |
Interfaces
3 interfaces between chains.
- A–C · 911 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 884 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 869 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6HOJ · Structure of Beclin1 LIR motif bound to GABARAP · the same entry in another collection · chain A against A, TM-score 1.00
- O95166 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated protein… · a predicted model of the same protein · chain A against A, TM-score 0.89
- Q14457 · AlphaFold monomer V2.0 prediction for beclin-1 (Q14457) · a predicted model of the same protein · chain B against A, TM-score 0.35
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14457
- Every structure of UniProt O95166
- Elsewhere: RCSB PDB 6HOJ · PDBe 6HOJ · UniProt Q14457 · UniProt O95166
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