MolNFT v1 · #15133 · protein
Crystal structure of the human rxr alpha ligand binding domain bound to the eicosanoid dha (docosa hexaenoic acid) and a coactivator peptide
1MV9 · Rxr retinoid X receptor: “Crystal structure of the human rxr alpha ligand binding domain bound to the eicosanoid dha (docosa hexaenoic…”. X-ray diffraction, 1 ligand (HXA), 2 pockets (best druggability 0.84). MolNFT v1 #15133 on…
- PDB
- 1MV9
- Type
- protein
- Length
- 225 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rxr retinoid X receptor; Nuclear receptor coactivator 2
- UniProt
- P19793, Q15596
- Ligands
- HXA
- Pockets
- 2 · best druggability 0.84
Structure
x-ray diffraction · 2 distinct chains · 70% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Rxr retinoid X receptor | protein | 214 | 70% helix, 3% strand | P19793 |
| B | Nuclear receptor coactivator 2 | protein | 11 | 73% helix, 0% strand | Q15596 |
Ligands and binding sites
- HXA · Docosa-4,7,10,13,16,19-hexaenoic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 330 | 0.84 | 0.93 | 40 | HXA |
| 2 | 194 | 0.46 | 0.74 | 31 | empty |
Interfaces
1 interface between chains.
- A–B · 622 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1MV9 · Crystal Structure of the human RXR alpha ligand binding domain bound to the eicosanoid… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19793
- Every structure of UniProt Q15596
- Elsewhere: RCSB PDB 1MV9 · PDBe 1MV9 · UniProt P19793 · UniProt Q15596
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