MolNFT v1 · #151269 · protein
X-ray structure of TEAD1(Y421H mutant) complexed with YAP(WILDTYPE): molecular and structural characterization of a tead mutation at the origin of SVEINSSON'S chorioretinal atrophy
6HIL · Transcriptional enhancer factor tef-1: “X-ray structure of TEAD1(Y421H mutant) complexed with YAP(WILDTYPE): molecular and structural…”. X-ray diffraction, 1 ligand (MYR), 18 pockets (best druggability 0.82). MolNFT v1 #151269 on…
- PDB
- 6HIL
- Type
- protein
- Length
- 951 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional enhancer factor tef-1; Transcriptional coactivator YAP1
- UniProt
- P28347, P46937
- Ligands
- MYR
- Pockets
- 18 · best druggability 0.82
Structure
x-ray diffraction · 3 distinct chains · 20% helix, 49% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional enhancer factor tef-1 | protein | 202 | 17% helix, 52% strand | P28347 |
| L, O, M, N | Transcriptional coactivator YAP1 | protein | 35 | 43% helix, 0% strand | P46937 |
| D, B, C | Transcriptional enhancer factor tef-1 | protein | 203 | 18% helix, 54% strand | P28347 |
Ligands and binding sites
- MYR · Myristic acid · ligand · 4 copies · chains A, D, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
18 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 193 | 0.82 | 0.95 | 37 | MYR |
| 2 | 181 | 0.81 | 0.95 | 29 | MYR |
| 3 | 182 | 0.81 | 0.95 | 37 | MYR |
| 4 | 176 | 0.81 | 0.95 | 33 | MYR |
| 5 | 616 | 0.70 | 0.78 | 68 | empty |
Interfaces
9 interfaces between chains.
- C–N · 1218 Ų buried · 10 hydrogen bonds · protein-protein
- A–L · 1180 Ų buried · 11 hydrogen bonds · protein-protein
- B–M · 1168 Ų buried · 10 hydrogen bonds · protein-protein
- D–O · 1139 Ų buried · 9 hydrogen bonds · protein-protein
- D–B · 956 Ų buried · 23 hydrogen bonds · protein-protein
Compared structures
- 6HIL · X-ray structure of TEAD1(Y421H mutant) complexed with YAP(wildtype): Molecular and… · the same entry in another collection · chain N against N, TM-score 1.00
- P28347 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-1 (P28347) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P46937 · AlphaFold monomer V2.0 prediction for transcriptional coactivator YAP1 (P46937) · a predicted model of the same protein · chain L against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P28347
- Every structure of UniProt P46937
- Elsewhere: RCSB PDB 6HIL · PDBe 6HIL · UniProt P28347 · UniProt P46937
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