MolNFT v1 · #151193 · protein
Crystal structure of the human il-17RC ecd in complex with human il- 17F, crystal form II
6HG9 · Interleukin-17F: “Crystal structure of the human il-17RC ecd in complex with human il- 17F, crystal form II”. X-ray diffraction, 3 pockets (best druggability 0.72). MolNFT v1 #151193 on GenesisL1: 3D structure, binding sites and…
- PDB
- 6HG9
- Type
- protein
- Length
- 532 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-17F; Interleukin-17 receptor C
- UniProt
- Q96PD4, Q8NAC3
- Pockets
- 3 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-17F | protein | 109 | 4% helix, 47% strand | Q96PD4 |
| B | Interleukin-17 receptor C | protein | 423 | 8% helix, 45% strand | Q8NAC3 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 863 | 0.72 | 0.77 | 73 | empty |
| 2 | 126 | 0.48 | 0.79 | 22 | empty |
| 3 | 115 | 0.41 | 0.75 | 20 | empty |
Interfaces
1 interface between chains.
- A–B · 1201 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 disulfide (disulfide).
Compared structures
- 6HG9 · Crystal Structure of the human IL-17RC ECD in complex with human IL-17F, Crystal form II · the same entry in another collection · chain A against A, TM-score 1.00
- Q8NAC3 · AlphaFold monomer V2.0 prediction for interleukin-17 receptor C (Q8NAC3) · a predicted model of the same protein · chain B against A, TM-score 0.92
- Q96PD4 · AlphaFold monomer V2.0 prediction for interleukin-17F (Q96PD4) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96PD4
- Every structure of UniProt Q8NAC3
- Elsewhere: RCSB PDB 6HG9 · PDBe 6HG9 · UniProt Q96PD4 · UniProt Q8NAC3
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