MolNFT v1 · #151188 · protein
Crystal structure of the human il-17RC ecd in complex with human il- 17F
6HG4 · Interleukin-17F: “Crystal structure of the human il-17RC ecd in complex with human il- 17F”. X-ray diffraction, 5 pockets (best druggability 0.72). MolNFT v1 #151188 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6HG4
- Type
- protein
- Length
- 531 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Interleukin-17F; Interleukin-17 receptor C
- UniProt
- Q96PD4, Q8NAC3
- Pockets
- 5 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Interleukin-17F | protein | 104 | 4% helix, 50% strand | Q96PD4 |
| B | Interleukin-17 receptor C | protein | 427 | 10% helix, 48% strand | Q8NAC3 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 739 | 0.72 | 0.78 | 63 | empty |
| 2 | 301 | 0.59 | 0.77 | 34 | empty |
| 3 | 70 | 0.44 | 0.82 | 17 | empty |
| 4 | 68 | 0.42 | 0.80 | 12 | empty |
| 5 | 53 | 0.28 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1174 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 13 disulfide (disulfide).
Compared structures
- 6HG4 · Crystal Structure of the human IL-17RC ECD in complex with human IL-17F · the same entry in another collection · chain A against A, TM-score 1.00
- Q8NAC3 · AlphaFold monomer V2.0 prediction for interleukin-17 receptor C (Q8NAC3) · a predicted model of the same protein · chain B against A, TM-score 0.95
- Q96PD4 · AlphaFold monomer V2.0 prediction for interleukin-17F (Q96PD4) · a predicted model of the same protein · chain A against A, TM-score 0.92
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q96PD4
- Every structure of UniProt Q8NAC3
- Elsewhere: RCSB PDB 6HG4 · PDBe 6HG4 · UniProt Q96PD4 · UniProt Q8NAC3
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