MolNFT v1 · #151185 · protein
Hybrid dihydroorotase domain of human cad with E. COLI flexible loop in apo state
6HG1 · Cad PROTEIN,DIHYDROOROTASE,CAD protein: “Hybrid dihydroorotase domain of human cad with E. COLI flexible loop in apo state”. X-ray diffraction, 1 ligand (ZN), 3 pockets (best druggability 0.57). MolNFT v1 #151185 on GenesisL1: 3D…
- PDB
- 6HG1
- Type
- protein
- Length
- 371 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cad PROTEIN,DIHYDROOROTASE,CAD protein
- EC
- 6.3.5.5, 2.1.3.2, 3.5.2.3
- UniProt
- P27708, P05020
- Ligands
- ZN
- Pockets
- 3 · best druggability 0.57
Structure
x-ray diffraction · 1 distinct chain · 35% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cad PROTEIN,DIHYDROOROTASE,CAD protein (EC 6.3.5.5, 2.1.3.2, 3.5.2.3) | protein | 371 | 35% helix, 20% strand | P27708, P05020 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 194 | 0.57 | 0.81 | 28 | empty |
| 2 | 84 | 0.44 | 0.80 | 18 | empty |
| 3 | 54 | 0.32 | 0.77 | 17 | FMT |
Modifications
Observed in the structure: 1 modified (carboxylation).
Compared structures
- 6HG1 · Hybrid dihydroorotase domain of human CAD with E. coli flexible loop in apo state · the same entry in another collection · chain A against A, TM-score 1.00
- P27708 · AlphaFold monomer V2.0 prediction for cad protein (P27708) · a predicted model of the same protein · chain A against A, TM-score 0.96
- P05020 · AlphaFold monomer V2.0 prediction for dihydroorotase (P05020) · a predicted model of the same protein · chain A against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P27708
- Every structure of UniProt P05020
- Elsewhere: RCSB PDB 6HG1 · PDBe 6HG1 · UniProt P27708 · UniProt P05020
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.