MolNFT v1 · #151137 · protein

Structure of human USP25

6HEL · Ubiquitin carboxyl-terminal hydrolase 25: “Structure of human USP25”. X-ray diffraction, 9 pockets (best druggability 0.70). MolNFT v1 #151137 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6HEL
Type: protein
Length: 926 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ubiquitin carboxyl-terminal hydrolase 25
EC: 3.4.19.12
UniProt: Q9UHP3
Pockets: 9 · best druggability 0.70

Structure

x-ray diffraction · 2 distinct chains · 42% helix, 17% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12)	protein	464	42% helix, 17% strand	Q9UHP3
B	Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12)	protein	462	42% helix, 17% strand	Q9UHP3

Pockets

9 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	395	0.70	0.81	45	empty
2	390	0.70	0.82	44	empty
3	377	0.68	0.81	37	empty
4	316	0.60	0.78	39	empty
5	197	0.48	0.75	24	empty

Interfaces

1 interface between chains.

A–B · 2084 Å² buried · 32 hydrogen bonds · protein-protein

Compared structures

6HEL · Structure of human USP25 · the same entry in another collection · chain A against A, TM-score 1.00
Q9UHP3 · AlphaFold monomer V2.0 prediction for ubiquitin carboxyl-terminal hydrolase 25 (Q9UHP3) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UHP3
Elsewhere: RCSB PDB 6HEL · PDBe 6HEL · UniProt Q9UHP3

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