MolNFT v1 · #15105 · protein
Structure of histone H3 K4-specific methyltransferase SET7/9
1MUF · SET9: “Structure of histone H3 K4-specific methyltransferase SET7/9”. X-ray diffraction, 3 pockets (best druggability 0.43). MolNFT v1 #15105 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1MUF
- Type
- protein
- Length
- 257 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SET9
- EC
- 2.1.1.43
- UniProt
- Q8WTS6
- Pockets
- 3 · best druggability 0.43
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | SET9 (EC 2.1.1.43) | protein | 257 | 6% helix, 46% strand | Q8WTS6 |
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 133 | 0.43 | 0.76 | 21 | empty |
| 2 | 66 | 0.35 | 0.77 | 22 | empty |
| 3 | 54 | 0.30 | 0.75 | 14 | empty |
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 1MUF · Structure of histone H3 K4-specific methyltransferase SET7/9 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8WTS6 · AlphaFold monomer V2.0 prediction for histone-lysine N-methyltransferase SETD7 (Q8WTS6) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WTS6
- Elsewhere: RCSB PDB 1MUF · PDBe 1MUF · UniProt Q8WTS6
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