Crystal structure of mycobacterium tuberculosis phosphatidylinositol phosphate synthase (PGSA1) in complex with manganese and citrate

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• LFA · Eicosane · ligand · 4 copies · chains A, B
• MN · Manganese (II) ion · metal · 7 copies · chains A, B
• SO4 · Sulfate ion · ion · chains A, B
• FLC · Citrate anion · additive · 3 copies · chains A, B
• OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 3 copies · chains A, B
• 1PE · Pentaethylene glycol · additive · 2 copies · chains B, A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6H5A · Crystal structure of Mycobacterium tuberculosis phosphatidylinositol phosphate synthase… · the same entry in another collection · chain A against A, TM-score 1.00
• P9WPG7 · AlphaFold monomer V2.0 prediction for phosphatidylinositol phosphate synthase (P9WPG7) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P9WPG7
• Elsewhere: RCSB PDB 6H5A · PDBe 6H5A · UniProt P9WPG7