MolNFT v1 · #150782 · protein
Crystal structure of the human tgt catalytic subunit QTRT1
6H42 · Queuine tRNA-ribosyltransferase catalytic subunit 1: “Crystal structure of the human tgt catalytic subunit QTRT1”. X-ray diffraction, 5 ligands (GGL, K, ZN), 11 pockets (best druggability 0.70). MolNFT v1 #150782 on GenesisL1: 3D…
- PDB
- 6H42
- Type
- protein
- Length
- 784 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Queuine tRNA-ribosyltransferase catalytic subunit 1
- EC
- 2.4.2.29
- UniProt
- Q9BXR0
- Ligands
- GGL, K, ZN, CL, BR
- Pockets
- 11 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 41% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.29) | protein | 393 | 41% helix, 17% strand | Q9BXR0 |
| B | Queuine tRNA-ribosyltransferase catalytic subunit 1 (EC 2.4.2.29) | protein | 391 | 41% helix, 17% strand | Q9BXR0 |
Ligands and binding sites
- GGL · Gamma-L-glutamic acid · ligand · chains B
- K · Potassium ion · metal · 2 copies · chains A, B
- ZN · Zinc ion · metal · 2 copies · chains A, B
- CL · Chloride ion · ion · 10 copies · chains A, B
- BR · Bromide ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 586 | 0.70 | 0.79 | 71 | CL |
| 2 | 461 | 0.69 | 0.80 | 57 | CL |
| 3 | 662 | 0.68 | 0.76 | 68 | CL |
| 4 | 119 | 0.46 | 0.78 | 22 | empty |
| 5 | 99 | 0.45 | 0.79 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 736 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 6H42 · crystal structure of the human TGT catalytic subunit QTRT1 · the same entry in another collection · chain B against B, TM-score 1.00
- Q9BXR0 · AlphaFold monomer V2.0 prediction for queuine tRNA-ribosyltransferase catalytic subunit 1… · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BXR0
- Elsewhere: RCSB PDB 6H42 · PDBe 6H42 · UniProt Q9BXR0
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.