CDK2/CYCLIN A2 in complex with PYRAZOLO[4,3-D]PYRIMIDINE inhibitor LGR4455

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• FCQ · 5-(2-azanylethylsulfanyl)-3-propan-2-yl-~{N}-[(4-pyridin-2-ylphenyl)methyl]-2~{H}-pyrazolo[4,3-d]pyrimidin-7-amine · ligand · chains A
• CL · Chloride ion · ion · chains A
• BR · Bromide ion · ion · chains A
• EDO · 1,2-ethanediol · additive · 3 copies · chains A, B
• PG4 · Tetraethylene glycol · additive · chains B
• SGM · Monothioglycerol · additive · chains B
• PGE · Triethylene glycol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6GVA · CDK2/cyclin A2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor LGR4455 · the same entry in another collection · chain A against A, TM-score 1.00
• P20248 · AlphaFold monomer V2.0 prediction for cyclin-A2 (P20248) · a predicted model of the same protein · chain B against A, TM-score 0.99
• P24941 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 2 (P24941) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P24941
• Every structure of UniProt P20248
• Elsewhere: RCSB PDB 6GVA · PDBe 6GVA · UniProt P24941 · UniProt P20248