MolNFT v1 · #150457 · protein
CDK1/CKS2 in complex with AZD5438
6GU7: “CDK1/CKS2 in complex with AZD5438”. X-ray diffraction, 1 ligand (FB8). MolNFT v1 #150457 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6GU7
- Type
- protein
- Length
- 1,427 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P06493, P33552
- Ligands
- FB8
Structure
x-ray diffraction · 7 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 284 | — | P06493 |
| B, D | — | protein | 71 | — | P33552 |
| C | — | protein | 291 | — | P06493 |
| E | — | protein | 284 | — | P06493 |
| F | — | protein | 71 | — | P33552 |
| G | — | protein | 283 | — | P06493 |
| H | — | protein | 72 | — | P33552 |
Ligands and binding sites
- FB8 · 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine · ligand · chains A, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6GU7 · CDK1/Cks2 in complex with AZD5438 · the same entry in another collection · chain H against H, TM-score 1.00
- P33552 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinases regulatory subunit 2… · a predicted model of the same protein · chain B against A, TM-score 0.96
- P06493 · AlphaFold monomer V2.0 prediction for cyclin-dependent kinase 1 (P06493) · a predicted model of the same protein · chain E against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06493
- Every structure of UniProt P33552
- Elsewhere: RCSB PDB 6GU7 · PDBe 6GU7 · UniProt P06493 · UniProt P33552
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