UniProt P33552
P33552
P33552 (UniProt P33552): 16 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P33552
- Experimental structures
- 16
- Predicted models
- 1
- Ligands
- 1
Structures
17 records of P33552 in the MolNFT archive: 16 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CKS | Human CKSHS2 atomic structure: a role for its hexameric assembly in cell cycle control | x-ray diffraction | A, B, C | — | — |
| 1CKS | Human CKSHS2 atomic structure: a role for its hexameric assembly in cell cycle control | x-ray diffraction | A, B, C | — | — |
| 4Y72 | Human CDK1/CyclinB1/CKS2 With Inhibitor | x-ray diffraction | C | — | — |
| 4Y72 | Human CDK1/CYCLINB1/CKS2 with inhibitor | x-ray diffraction | C | — | — |
| 4YC3 | CDK1/CyclinB1/CKS2 Apo | x-ray diffraction | C | — | — |
| 4YC3 | CDK1/CYCLINB1/CKS2 apo | x-ray diffraction | C | — | — |
| 5HQ0 | Ternary complex of human proteins CDK1, Cyclin B and CKS2, bound to an inhibitor | x-ray diffraction | C | — | — |
| 5HQ0 | Ternary complex of human proteins CDK1, cyclin B and CKS2, bound to an inhibitor | x-ray diffraction | C | — | — |
| 5LQF | CDK1/CyclinB1/CKS2 in complex with NU6102 | x-ray diffraction | C, F | — | — |
| 5LQF | CDK1/CYCLINB1/CKS2 in complex with NU6102 | x-ray diffraction | C, F | — | — |
| 6GU2 | CDK1/CyclinB/Cks2 in complex with Flavopiridol | x-ray diffraction | C | — | — |
| 6GU2 | CDK1/CYCLINB/CKS2 in complex with flavopiridol | x-ray diffraction | C | — | — |
| 6GU3 | CDK1/CYCLINB/CKS2 in complex with AZD5438 | x-ray diffraction | C | — | — |
| 6GU4 | CDK1/CYCLINB/CKS2 in complex with CGP74514A | x-ray diffraction | C | — | — |
| 6GU6 | CDK1/CKS2 in complex with dinaciclib | x-ray diffraction | B | — | — |
| 6GU7 | CDK1/CKS2 in complex with AZD5438 | x-ray diffraction | B, D, F, H | FB8 | — |
| P33552 | AlphaFold monomer V2.0 prediction for cyclin-dependent kinases regulatory subunit 2 (P33552) | predicted | A | — | — |
Ligands
- FB8 · 4-(2-methyl-3-propan-2-yl-imidazol-4-yl)-~{N}-(4-methylsulfonylphenyl)pyrimidin-2-amine · in 1 record
Experiment against prediction
- 6GU2 chain C against the predicted model P33552: TM-score 0.98, RMSD 0.43 Å
- 6GU2 chain C against the predicted model P33552: TM-score 0.98, RMSD 0.43 Å
- 4YC3 chain C against the predicted model P33552: TM-score 0.97, RMSD 0.51 Å
- 4YC3 chain C against the predicted model P33552: TM-score 0.97, RMSD 0.51 Å
- 6GU7 chain B against the predicted model P33552: TM-score 0.96, RMSD 0.60 Å
- 6GU7 chain H against the predicted model P33552: TM-score 0.96, RMSD 0.64 Å
- 6GU7 chain D against the predicted model P33552: TM-score 0.96, RMSD 0.64 Å
- 6GU7 chain F against the predicted model P33552: TM-score 0.96, RMSD 0.67 Å
- 5LQF chain F against the predicted model P33552: TM-score 0.94, RMSD 1.05 Å
- 5LQF chain F against the predicted model P33552: TM-score 0.94, RMSD 1.05 Å
Elsewhere
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