MolNFT v1 · #150338 · protein
Crystal structure of human C-kit kinase domain in complex with AZD3229-analogue (compound 35)
6GQL: “Crystal structure of human C-kit kinase domain in complex with AZD3229-analogue (compound 35)”. X-ray diffraction, 1 ligand (F8B). MolNFT v1 #150338 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 6GQL
- Type
- protein
- Length
- 584 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P10721
- Ligands
- F8B
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 298 | — | P10721 |
| B | — | protein | 286 | — | P10721 |
Ligands and binding sites
- F8B · ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 6GQL · Crystal structure of human c-KIT kinase domain in complex with AZD3229-analogue (compound… · the same entry in another collection · chain A against A, TM-score 1.00
- P10721 · AlphaFold monomer V2.0 prediction for MAST/STEM cell growth factor receptor kit (P10721) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10721
- Elsewhere: RCSB PDB 6GQL · PDBe 6GQL · UniProt P10721
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