MolNFT v1 · #149920 · protein
TEAD4 (216-434) complexed with yap peptide (60-100);S94A and myristoate (covalently bound) at 1.70A (P41212 crystal form); myristoylation was done by adding myr-CoA
6GEC · Transcriptional enhancer factor tef-3: “TEAD4 (216-434) complexed with yap peptide (60-100);S94A and myristoate (covalently bound) at 1.70A (P41212…”. X-ray diffraction, 2 ligands (ACE, MYR), 3 pockets (best druggability 0.81).…
- PDB
- 6GEC
- Type
- protein
- Length
- 247 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional enhancer factor tef-3; Transcriptional coactivator YAP1
- UniProt
- Q15561, P46937
- Ligands
- ACE, MYR
- Pockets
- 3 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional enhancer factor tef-3 | protein | 207 | 17% helix, 53% strand | Q15561 |
| L | Transcriptional coactivator YAP1 | protein | 40 | 38% helix, 0% strand | P46937 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 164 | 0.81 | 0.96 | 36 | MYR |
| 2 | 61 | 0.31 | 0.75 | 15 | empty |
| 3 | 60 | 0.28 | 0.74 | 18 | empty |
Interfaces
1 interface between chains.
- A–L · 1357 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 covalent, 1 lipid (covalent ligand, myristoylation).
Compared structures
- 6GEC · TEAD4 (216-434) complexed with yap peptide (60-100);S94A and myristoate (covalently… · the same entry in another collection · chain A against A, TM-score 1.00
- Q15561 · AlphaFold monomer V2.0 prediction for transcriptional enhancer factor tef-3 (Q15561) · a predicted model of the same protein · chain A against A, TM-score 0.98
- P46937 · AlphaFold monomer V2.0 prediction for transcriptional coactivator YAP1 (P46937) · a predicted model of the same protein · chain L against A, TM-score 0.42
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q15561
- Every structure of UniProt P46937
- Elsewhere: RCSB PDB 6GEC · PDBe 6GEC · UniProt Q15561 · UniProt P46937
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