MolNFT v1 · #149893 · protein

Calcium bound form of human calmodulin mutant F141L

6GDK · Calmodulin-1: “Calcium bound form of human calmodulin mutant F141L”. Solution nmr, 1 ligand (CA), 2 pockets (best druggability 0.53). MolNFT v1 #149893 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6GDK
Type: protein
Length: 148 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Calmodulin-1
UniProt: P0DP23
Ligands: CA
Pockets: 2 · best druggability 0.53

Structure

solution nmr · 1 distinct chain · 56% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Calmodulin-1	protein	148	56% helix, 4% strand	P0DP23

Ligands and binding sites

CA · Calcium ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	195	0.53	0.78	20	empty
2	121	0.51	0.80	21	empty

Compared structures

6GDK · Calcium bound form of human calmodulin mutant F141L · the same entry in another collection · chain A against A, TM-score 1.00
P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain A against A, TM-score 0.44

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0DP23
Elsewhere: RCSB PDB 6GDK · PDBe 6GDK · UniProt P0DP23

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