14-3-3SIGMA in complex with a P129BETA3P mutated yap PS127 phosphopeptide

Structure

x-ray diffraction · 2 distinct chains · 77% helix, 0% strand (DSSP).

Ligands and binding sites

• EOE · Beta3-proline · ligand · chains A, P
• NA · Sodium ion · metal · 2 copies · chains A
• CL · Chloride ion · ion · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–P · 615 Ų buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 covalent, 1 modified (covalent ligand, phosphorylation).

Compared structures

• 6G6X · 14-3-3sigma in complex with a P129beta3P mutated YAP pS127 phosphopeptide · the same entry in another collection · chain A against A, TM-score 1.00
• P31947 · AlphaFold monomer V2.0 prediction for 14-3-3 protein sigma (P31947) · a predicted model of the same protein · chain A against A, TM-score 0.95
• P46937 · AlphaFold monomer V2.0 prediction for transcriptional coactivator YAP1 (P46937) · a predicted model of the same protein · chain P against A, TM-score 0.48

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P31947
• Every structure of UniProt P46937
• Elsewhere: RCSB PDB 6G6X · PDBe 6G6X · UniProt P31947 · UniProt P46937