MolNFT v1 · #149108 · protein
GLUA2(FLOP) S729C ligand binding core dimer bound to nbqx at 1.76 ångström resolution
6FQH · Glutamate receptor 2,GLUTAMATE receptor 2: “GLUA2(FLOP) S729C ligand binding core dimer bound to nbqx at 1.76 ångström resolution”. X-ray diffraction, 1 ligand (E2Q), 5 pockets (best druggability 0.75). MolNFT v1 #149108 on…
- PDB
- 6FQH
- Type
- protein
- Length
- 517 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutamate receptor 2,GLUTAMATE receptor 2
- UniProt
- P19491
- Ligands
- E2Q
- Pockets
- 5 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Glutamate receptor 2,GLUTAMATE receptor 2 | protein | 259 | 38% helix, 21% strand | P19491 |
| B | Glutamate receptor 2,GLUTAMATE receptor 2 | protein | 258 | 38% helix, 23% strand | P19491 |
Ligands and binding sites
- E2Q · 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 160 | 0.75 | 0.92 | 26 | empty |
| 2 | 987 | 0.74 | 0.77 | 78 | empty |
| 3 | 212 | 0.60 | 0.81 | 41 | empty |
| 4 | 228 | 0.53 | 0.77 | 30 | E2Q |
| 5 | 159 | 0.53 | 0.80 | 21 | E2Q |
Interfaces
1 interface between chains.
- A–B · 977 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 6FQH · GluA2(flop) S729C ligand binding core dimer bound to NBQX at 1.76 Angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P19491
- Elsewhere: RCSB PDB 6FQH · PDBe 6FQH · UniProt P19491
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.