MolNFT v1 · #149078 · protein

TETR(D) E147A mutant in complex with tetracycline and magnesium

6FPL · Tetracycline repressor protein class D: “TETR(D) E147A mutant in complex with tetracycline and magnesium”. X-ray diffraction, 3 ligands (TAC, MG, CL), 1 pocket (best druggability 0.64). MolNFT v1 #149078 on GenesisL1: 3D structure…

PDB: 6FPL
Type: protein
Length: 198 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tetracycline repressor protein class D
UniProt: P0ACT4
Ligands: TAC, MG, CL
Pockets: 1 · best druggability 0.64

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Tetracycline repressor protein class D	protein	198	73% helix, 0% strand	P0ACT4

Ligands and binding sites

TAC · Tetracycline · ligand · chains A
MG · Magnesium ion · metal · chains A
CL · Chloride ion · ion · 6 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	301	0.64	0.80	34	TAC, MG, CL

Compared structures

6FPL · TETR(D) E147A mutant in complex with tetracycline and magnesium · the same entry in another collection · chain A against A, TM-score 1.00
P0ACT4 · AlphaFold monomer V2.0 prediction for tetracycline repressor protein class D (P0ACT4) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0ACT4
Elsewhere: RCSB PDB 6FPL · PDBe 6FPL · UniProt P0ACT4

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