MolNFT v1 · #149050 · protein
Elongated conformer of the human copper chaperone for SOD1 complexed with human SOD1
6FON · Copper chaperone for superoxide dismutase: “Elongated conformer of the human copper chaperone for SOD1 complexed with human SOD1”. X-ray diffraction, 1 ligand (ZN), 6 pockets (best druggability 0.57). MolNFT v1 #149050 on GenesisL1…
- PDB
- 6FON
- Type
- protein
- Length
- 810 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Copper chaperone for superoxide dismutase; Superoxide dismutase [cu-zn]
- EC
- 1.15.1.1
- UniProt
- O14618, P00441
- Ligands
- ZN
- Pockets
- 6 · best druggability 0.57
Structure
x-ray diffraction · 2 distinct chains · 9% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Copper chaperone for superoxide dismutase | protein | 252 | 12% helix, 41% strand | O14618 |
| B, D | Superoxide dismutase [cu-zn] (EC 1.15.1.1) | protein | 153 | 5% helix, 41% strand | P00441 |
Ligands and binding sites
- ZN · Zinc ion · metal · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 313 | 0.57 | 0.76 | 39 | empty |
| 2 | 358 | 0.57 | 0.75 | 42 | empty |
| 3 | 171 | 0.55 | 0.80 | 24 | empty |
| 4 | 202 | 0.54 | 0.79 | 29 | empty |
| 5 | 125 | 0.41 | 0.76 | 25 | empty |
Interfaces
3 interfaces between chains.
- C–D · 778 Ų buried · 9 hydrogen bonds · protein-protein
- A–B · 778 Ų buried · 7 hydrogen bonds · protein-protein
- A–C · 229 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
- 6FON · Elongated conformer of the human copper chaperone for SOD1 complexed with human SOD1 · the same entry in another collection · chain A against A, TM-score 1.00
- O14618 · AlphaFold monomer V2.0 prediction for copper chaperone for superoxide dismutase (O14618) · a predicted model of the same protein · chain A against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O14618
- Every structure of UniProt P00441
- Elsewhere: RCSB PDB 6FON · PDBe 6FON · UniProt O14618 · UniProt P00441
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