UniProt O14618
Copper chaperone for superoxide dismutase (O14618)
Copper chaperone for superoxide dismutase (UniProt O14618): 12 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 1 pocket. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O14618
- Protein
- Copper chaperone for superoxide dismutase
- Experimental structures
- 12
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 1 · 0 records with a druggable one
Structures
13 records of O14618 in the MolNFT archive: 12 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1DO5 | Human copper chaperone for superoxide dismutase domain II | x-ray diffraction | A, B, C, D | — | — |
| 1DO5 | Human copper chaperone for superoxide dismutase domain II | x-ray diffraction | A, B, C, D | — | — |
| 2CRL | The apo form of HMA domain of copper chaperone for superoxide dismutase | solution nmr | A | — | — |
| 2CRL | The apo form of hma domain of copper chaperone for superoxide dismutase | solution nmr | A | — | — |
| 2RSQ | Copper(I) loaded form of the first domain of the human copper chaperone for SOD1, CCS | solution nmr | A | — | — |
| 2RSQ | COPPER(I) loaded form of the first domain of the human copper chaperone for SOD1, ccs | solution nmr | A | — | — |
| 6FN8 | Domain II of the HUMAN COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE at 1.55 A resolution | x-ray diffraction | A, B | ZN | 1 (best 0.42) |
| 6FN8 | Domain II of the human copper chaperone for superoxide dismutase at 1.55 a resolution | x-ray diffraction | A, B | ZN | — |
| 6FOL | Domain II of the human copper chaperone in complex with human CU,ZN superoxide dismutase | x-ray diffraction | A, D, E, H | ZN | — |
| 6FON | Elongated conformer of the human copper chaperone for SOD1 complexed with human SOD1 | x-ray diffraction | A, C | ZN | — |
| 6FON | Elongated conformer of the human copper chaperone for SOD1 complexed with human SOD1 | x-ray diffraction | A, C | ZN | — |
| 6FP6 | Complex of human CU,ZN SOD1 with the human copper chaperone for SOD1 in a compact conformation | x-ray diffraction | B, D, F, H, J, L, N, P, R, T, V, X | ZN | — |
| O14618 | AlphaFold monomer V2.0 prediction for copper chaperone for superoxide dismutase (O14618) | predicted | A | — | — |
Ligands
- ZN · Zinc ion · in 6 records
Experiment against prediction
- 6FP6 chain J against the predicted model O14618: TM-score 1.00, RMSD 0.34 Å
- 6FP6 chain V against the predicted model O14618: TM-score 1.00, RMSD 0.29 Å
- 6FOL chain A against the predicted model O14618: TM-score 1.00, RMSD 0.32 Å
- 6FOL chain D against the predicted model O14618: TM-score 0.99, RMSD 0.33 Å
- 6FP6 chain T against the predicted model O14618: TM-score 0.99, RMSD 0.42 Å
- 6FP6 chain H against the predicted model O14618: TM-score 0.99, RMSD 0.44 Å
- 6FOL chain H against the predicted model O14618: TM-score 0.99, RMSD 0.38 Å
- 6FP6 chain P against the predicted model O14618: TM-score 0.99, RMSD 0.51 Å
- 6FOL chain E against the predicted model O14618: TM-score 0.99, RMSD 0.44 Å
- 6FP6 chain D against the predicted model O14618: TM-score 0.99, RMSD 0.56 Å
Elsewhere
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