MolNFT v1 · #149024 · protein
Structure of S. cerevisiae methylenetetrahydrofolate reductase 1, catalytic domain
6FNU: “Structure of S. cerevisiae methylenetetrahydrofolate reductase 1, catalytic domain”. X-ray diffraction, 1 ligand (FAD), 3 pockets (best druggability 0.69). MolNFT v1 #149024 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 6FNU
- Type
- protein
- Length
- 296 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Methylenetetrahydrofolate reductase 1
- EC
- 1.5.1.20
- UniProt
- P46151
- Ligands
- FAD
- Pockets
- 3 · best druggability 0.69
Structure
x-ray diffraction · 1 distinct chain · 51% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Methylenetetrahydrofolate reductase 1 (EC 1.5.1.20) | protein | 296 | 51% helix, 14% strand | P46151 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 589 | 0.69 | 0.78 | 56 | FAD |
| 2 | 90 | 0.41 | 0.78 | 16 | empty |
| 3 | 60 | 0.29 | 0.74 | 12 | empty |
Compared structures
- 6FNU · Structure of S. cerevisiae Methylenetetrahydrofolate reductase 1, catalytic domain · the same entry in another collection · chain A against A, TM-score 1.00
- P46151 · AlphaFold monomer V2.0 prediction for methylenetetrahydrofolate reductase 1 (P46151) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46151
- Elsewhere: RCSB PDB 6FNU · PDBe 6FNU · UniProt P46151
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