MolNFT v1 · #148980 · protein

PVHL:ELOB:ELOC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4- methylthiazol-5-YL)BENZYL)CARBAMOTHIOYL) pyrrolidin-1-yl)-1- thioxopropan-2-YL)ACETAMIDE (ligand 4)

6FMK: “PVHL:ELOB:ELOC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4- methylthiazol-5-YL)BENZYL)CARBAMOTHIOYL)…”. X-ray diffraction, 1 ligand (DV8). MolNFT v1 #148980 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6FMK
Type: protein
Length: 1,338 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q15370, Q15369, P40337
Ligands: DV8

Structure

x-ray diffraction · 8 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	104	—	Q15370
B	—	protein	87	—	Q15369
C	—	protein	141	—	P40337
D, G, J	—	protein	103	—	Q15370
E	—	protein	91	—	Q15369
F, I, L	—	protein	143	—	P40337
H	—	protein	89	—	Q15369
K	—	protein	88	—	Q15369

Ligands and binding sites

DV8 · ~{N}-[(2~{S})-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamothioyl]-4-oxidanyl-pyrrolidin-1-yl]-1-sulfanylidene-propan-2-yl]ethanamide · ligand · 4 copies · chains C, L, F, I

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6FMK · pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)ben… · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15370
Every structure of UniProt Q15369
Every structure of UniProt P40337
Elsewhere: RCSB PDB 6FMK · PDBe 6FMK · UniProt Q15370 · UniProt Q15369 · UniProt P40337

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