Research workbench

PVHL:ELOB:ELOC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4- methylthiazol-5-YL)BENZYL)CARBAMOTHIOYL) pyrrolidin-1-yl)-1- thioxopropan-2-YL)ACETAMIDE (ligand 4)

Analyse PVHL:ELOB:ELOC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 6FMK
Type: protein
Length: 1,338 residues
Chains: 12
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Elongin-B; Elongin-C; Von hippel-lindau disease tumor suppressor
UniProt: Q15370, Q15369, P40337
Ligands: DV8
Pockets: 12 · best druggability 0.62

Structure

x-ray diffraction · 8 distinct chains · 33% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Elongin-B	protein	104	17% helix, 37% strand	Q15370
B	Elongin-C	protein	87	48% helix, 15% strand	Q15369
C	Von hippel-lindau disease tumor suppressor	protein	141	26% helix, 30% strand	P40337
D, G, J	Elongin-B	protein	103	15% helix, 35% strand	Q15370
E	Elongin-C	protein	91	46% helix, 14% strand	Q15369
F, I, L	Von hippel-lindau disease tumor suppressor	protein	143	27% helix, 29% strand	P40337
H	Elongin-C	protein	89	46% helix, 15% strand	Q15369
K	Elongin-C	protein	88	48% helix, 15% strand	Q15369

Ligands and binding sites

DV8 · ~{N}-[(2~{S})-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamothioyl]-4-oxidanyl-pyrrolidin-1-yl]-1-sulfanylidene-propan-2-yl]ethanamide · ligand · 4 copies · chains C, L, F, I

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

12 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	240	0.62	0.80	32	DV8
2	104	0.59	0.86	22	empty
3	175	0.49	0.77	22	DV8
4	157	0.43	0.74	24	empty
5	63	0.42	0.81	18	empty

Interfaces

18 interfaces between chains.

G–H · 1159 Å² buried · 11 hydrogen bonds · protein-protein
J–K · 1144 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 1141 Å² buried · 12 hydrogen bonds · protein-protein
D–E · 1137 Å² buried · 11 hydrogen bonds · protein-protein
H–I · 1082 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (artifact).

Compared structures

6FMK · pVHL:EloB:EloC in complex with N-((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)ben… · the same entry in another collection · chain K against K, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q15370
Every structure of UniProt Q15369
Every structure of UniProt P40337
Elsewhere: RCSB PDB 6FMK · PDBe 6FMK · UniProt Q15370 · UniProt Q15369 · UniProt P40337

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.