Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase (hdhodh) inhibitors based on 2-HYDROXYPYRAZOLO[1,5- A]PYRIDINE scaffold

Structure

x-ray diffraction · 1 distinct chain.

Ligands and binding sites

• DUH · 2-oxidanyl-~{N}-[2,3,5,6-tetrakis(fluoranyl)-4-phenyl-phenyl]pyrazolo[1,5-a]pyridine-3-carboxamide · ligand · chains A
• FMN · Flavin mononucleotide · ligand · chains A
• ORO · Orotic acid · ligand · chains A
• CL · Chloride ion · ion · 2 copies · chains A
• ACT · Acetate ion · additive · 6 copies · chains A
• PGE · Triethylene glycol · additive · 6 copies · chains A
• GOL · Glycerol · additive · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6FMD · Targeting myeloid differentiation using potent human dihydroorotate dehydrogenase… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q02127
• Elsewhere: RCSB PDB 6FMD · PDBe 6FMD · UniProt Q02127