MolNFT v1 · #148813 · protein
Crystal structure of human BAZ2B phd zinc finger in complex with fr 21
6FHQ · Bromodomain adjacent to zinc finger domain protein 2B: “Crystal structure of human BAZ2B phd zinc finger in complex with fr 21”. X-ray diffraction, 2 ligands (DE5, ZN), 1 pocket (best druggability 0.44). MolNFT v1 #148813 on…
- PDB
- 6FHQ
- Type
- protein
- Length
- 115 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bromodomain adjacent to zinc finger domain protein 2B
- UniProt
- Q9UIF8
- Ligands
- DE5, ZN
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bromodomain adjacent to zinc finger domain protein 2B | protein | 58 | 17% helix, 14% strand | Q9UIF8 |
| B | Bromodomain adjacent to zinc finger domain protein 2B | protein | 57 | 23% helix, 14% strand | Q9UIF8 |
Ligands and binding sites
- DE5 · 2-azanyl-~{N}-(1,3-thiazol-2-yl)ethanamide · ligand · chains A
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.44 | 0.82 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 792 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6FHQ · Crystal structure of human BAZ2B PHD zinc finger in complex with Fr 21 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UIF8 · AlphaFold monomer V2.0 prediction for bromodomain adjacent to zinc finger domain protein… · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UIF8
- Elsewhere: RCSB PDB 6FHQ · PDBe 6FHQ · UniProt Q9UIF8
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