Research workbench
Crystal structure of human BAZ2B phd zinc finger in complex with fr 21
Analyse Crystal structure of human BAZ2B phd zinc finger in complex with fr 21 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 6FHQ
- Type
- protein
- Length
- 115 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bromodomain adjacent to zinc finger domain protein 2B
- UniProt
- Q9UIF8
- Ligands
- DE5, ZN
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 20% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bromodomain adjacent to zinc finger domain protein 2B | protein | 58 | 17% helix, 14% strand | Q9UIF8 |
| B | Bromodomain adjacent to zinc finger domain protein 2B | protein | 57 | 23% helix, 14% strand | Q9UIF8 |
Ligands and binding sites
- DE5 · 2-azanyl-~{N}-(1,3-thiazol-2-yl)ethanamide · ligand · chains A
- ZN · Zinc ion · metal · 4 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 65 | 0.44 | 0.82 | 21 | empty |
Interfaces
1 interface between chains.
- A–B · 792 Ų buried · 11 hydrogen bonds · protein-protein
Compared structures
- 6FHQ · Crystal structure of human BAZ2B PHD zinc finger in complex with Fr 21 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UIF8 · AlphaFold monomer V2.0 prediction for bromodomain adjacent to zinc finger domain protein… · a predicted model of the same protein · chain A against A, TM-score 0.85
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UIF8
- Elsewhere: RCSB PDB 6FHQ · PDBe 6FHQ · UniProt Q9UIF8
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.