MolNFT v1 · #14876 · protein

Structure of human neutrophil collagenase reveals large S1' specificity pocket

1MNC: “Structure of human neutrophil collagenase reveals large S1' specificity pocket”. X-ray diffraction, 3 ligands (PLH, ZN, CA), 1 pocket (best druggability 0.56). MolNFT v1 #14876 on GenesisL1: 3D structure, binding sites and pockets…

PDB: 1MNC
Type: protein
Length: 158 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Neutrophil collagenase
EC: 3.4.24.7
UniProt: P22894
Ligands: PLH, ZN, CA
Pockets: 1 · best druggability 0.56

Structure

x-ray diffraction · 1 distinct chain · 25% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Neutrophil collagenase (EC 3.4.24.7)	protein	158	25% helix, 16% strand	P22894

Ligands and binding sites

PLH · Methylamino-phenylalanyl-leucyl-hydroxamic acid · ligand · chains A
ZN · Zinc ion · metal · 2 copies · chains A
CA · Calcium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	128	0.56	0.83	23	PLH

Compared structures

1MNC · Structure of human neutrophil collagenase reveals large S1' specificity pocket · the same entry in another collection · chain A against A, TM-score 1.00
P22894 · AlphaFold monomer V2.0 prediction for neutrophil collagenase (P22894) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P22894
Elsewhere: RCSB PDB 1MNC · PDBe 1MNC · UniProt P22894

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