UniProt P22894
Neutrophil collagenase (P22894)
Neutrophil collagenase (UniProt P22894): 50 experimental structures and 1 predicted model on GenesisL1, 4 ligands bound, 7 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P22894
- Protein
- Neutrophil collagenase
- Experimental structures
- 50
- Predicted models
- 1
- Ligands
- 4
- Pockets
- 7 · 1 record with a druggable one
Structures
51 records of P22894 in the MolNFT archive: 50 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1A85 | MMP8 with malonic and asparagine based inhibitor | x-ray diffraction | A | — | — |
| 1A85 | MMP8 with malonic and asparagine based inhibitor | x-ray diffraction | A | — | — |
| 1A86 | MMP8 with malonic and aspartic acid based inhibitor | x-ray diffraction | A | — | — |
| 1A86 | MMP8 with malonic and aspartic acid based inhibitor | x-ray diffraction | A | — | — |
| 1BZS | Crystal structure of MMP8 complexed with HMR2909 | x-ray diffraction | A | — | — |
| 1BZS | Crystal structure of MMP8 complexed with HMR2909 | x-ray diffraction | A | — | — |
| 1I73 | Complex of pro-leu-L-TRP phosphonate with the catalitic domain of matrix metallo proteinase-8… | x-ray diffraction | A | — | — |
| 1I73 | Complex of pro-leu-L-TRP phosphonate with the catalitic domain of matrix metallo proteinase-8… | x-ray diffraction | A | — | — |
| 1I76 | Complex of 2-(biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (D-tic… | x-ray diffraction | A | — | — |
| 1I76 | Complex of 2-(biphenyl-4-sulfonyl)-1,2,3,4-tetrahydro-isoquinoline-3- carboxylic acid (D-tic… | x-ray diffraction | A | — | — |
| 1JAN | Complex of pro-leu-gly-hydroxylamine with the catalytic domain of matrix metallo proteinase-8… | x-ray diffraction | A | — | — |
| 1JAN | Complex of pro-leu-gly-hydroxylamine with the catalytic domain of matrix metallo proteinase-8… | x-ray diffraction | A | — | — |
| 1JAO | Complex of 3-mercapto-2-benzylpropanoyl-ala-gly-NH2 with the catalytic domain of matrix metallo… | x-ray diffraction | A | — | — |
| 1JAO | Complex of 3-mercapto-2-benzylpropanoyl-ala-gly-NH2 with the catalytic domain of matrix metallo… | x-ray diffraction | A | — | — |
| 1JAP | Complex of pro-leu-gly-hydroxylamine with the catalytic domain of matrix metallo proteinase-8… | x-ray diffraction | A | — | — |
| 1JAP | Complex of pro-leu-gly-hydroxylamine with the catalytic domain of matrix metallo proteinase-8… | x-ray diffraction | A | — | — |
| 1JAQ | Complex of 1-hydroxylamine-2-isobutylmalonyl-ala-gly-NH2 with the catalytic domain of matrix… | x-ray diffraction | A | — | — |
| 1JAQ | Complex of 1-hydroxylamine-2-isobutylmalonyl-ala-gly-NH2 with the catalytic domain of matrix… | x-ray diffraction | A | — | — |
| 1JH1 | Crystal Structure of MMP-8 complexed with a 6H-1,3,4-thiadiazine derived inhibitor | x-ray diffraction | A | — | — |
| 1JH1 | Crystal structure of mmp-8 complexed with a 6H-1,3,4- thiadiazine derived inhibitor | x-ray diffraction | A | — | — |
| 1JJ9 | Crystal Structure of MMP8-Barbiturate Complex Reveals Mechanism for Collagen Substrate Recognition | x-ray diffraction | A | — | — |
| 1JJ9 | Crystal structure of MMP8-barbiturate complex reveals mechanism for collagen substrate recognition | x-ray diffraction | A | — | — |
| 1KBC | Procarboxypeptidase ternary complex | x-ray diffraction | A, B | — | — |
| 1KBC | Procarboxypeptidase ternary complex | x-ray diffraction | A, B | — | — |
| 1MMB | Complex of BB94 with the catalytic domain of matrix metalloproteinase-8 | x-ray diffraction | A | — | — |
| 1MMB | Complex of BB94 with the catalytic domain of matrix metalloproteinase-8 | x-ray diffraction | A | — | — |
| 1MNC | Structure of human neutrophil collagenase reveals large S1' specificity pocket | x-ray diffraction | A | — | — |
| 1MNC | Structure of human neutrophil collagenase reveals large S1' specificity pocket | x-ray diffraction | A | — | — |
| 1ZP5 | Crystal structure of the complex between MMP-8 and a N-hydroxyurea inhibitor | x-ray diffraction | A | — | — |
| 1ZP5 | Crystal structure of the complex between mmp-8 and a N-hydroxyurea inhibitor | x-ray diffraction | A | — | — |
| 1ZS0 | Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (S-enantiomer) | x-ray diffraction | A | — | — |
| 1ZS0 | Crystal structure of the complex between mmp-8 and a phosphonate inhibitor (S-enantiomer) | x-ray diffraction | A | — | — |
| 1ZVX | Crystal structure of the complex between MMP-8 and a phosphonate inhibitor (R-enantiomer) | x-ray diffraction | A | — | — |
| 1ZVX | Crystal structure of the complex between mmp-8 and a phosphonate inhibitor (R-enantiomer) | x-ray diffraction | A | — | — |
| 2OY2 | Human MMP-8 in complex with peptide IAG | x-ray diffraction | A, F | — | — |
| 2OY2 | Human mmp-8 in complex with peptide iag | x-ray diffraction | A, F | — | — |
| 2OY4 | Uninhibited human MMP-8 | x-ray diffraction | A, F | — | — |
| 2OY4 | Uninhibited human mmp-8 | x-ray diffraction | A, F | — | — |
| 3DNG | Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor | x-ray diffraction | A, B | — | — |
| 3DNG | Crystal structure of the complex between mmp-8 and a non-zinc chelating inhibitor | x-ray diffraction | A, B | — | — |
| 3DPE | Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor | x-ray diffraction | A | — | — |
| 3DPE | Crystal structure of the complex between mmp-8 and a non-zinc chelating inhibitor | x-ray diffraction | A | — | — |
| 3DPF | Crystal structure of the complex between MMP-8 and a non-zinc chelating inhibitor | x-ray diffraction | A, B | — | — |
| 3DPF | Crystal structure of the complex between mmp-8 and a non-zinc chelating inhibitor | x-ray diffraction | A, B | — | — |
| 3TT4 | Human MMP8 in complex with L-glutamate motif inhibitor | x-ray diffraction | A | — | — |
| 3TT4 | Human MMP8 in complex with L-glutamate motif inhibitor | x-ray diffraction | A | — | — |
| 4QKZ | X-ray structure of the catalytic domain of MMP-8 with the inhibitor ML115 | x-ray diffraction | A | — | — |
| 4QKZ | X-ray structure of the catalytic domain of mmp-8 with the inhibitor ML115 | x-ray diffraction | A | — | — |
| 5H8X | Crystal structure of the complex MMP-8/BF471 (catechol inhibitor) | x-ray diffraction | A | CA, ZN, 5XT, 7FY | — |
| 5H8X | Crystal structure of the complex mmp-8/BF471 (catechol inhibitor) | x-ray diffraction | A | — | — |
| P22894 | AlphaFold monomer V2.0 prediction for neutrophil collagenase (P22894) | predicted | A | — | 7 (best 0.54) |
Ligands
Experiment against prediction
- 1JAP chain A against the predicted model P22894: TM-score 0.99, RMSD 0.45 Å
- 1JAP chain A against the predicted model P22894: TM-score 0.99, RMSD 0.45 Å
- 1MMB chain A against the predicted model P22894: TM-score 0.99, RMSD 0.45 Å
- 1MMB chain A against the predicted model P22894: TM-score 0.99, RMSD 0.45 Å
- 1JJ9 chain A against the predicted model P22894: TM-score 0.99, RMSD 0.45 Å
- 1JJ9 chain A against the predicted model P22894: TM-score 0.99, RMSD 0.45 Å
- 3TT4 chain A against the predicted model P22894: TM-score 0.99, RMSD 0.47 Å
- 3TT4 chain A against the predicted model P22894: TM-score 0.99, RMSD 0.47 Å
- 2OY2 chain A against the predicted model P22894: TM-score 0.99, RMSD 0.49 Å
- 2OY2 chain A against the predicted model P22894: TM-score 0.99, RMSD 0.49 Å
Elsewhere
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