MolNFT v1 · #148315 · protein
Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine.
6F34: “Crystal structure of a bacterial cationic amino acid transporter (cat) homologue bound to arginine.”. X-ray diffraction, 2 ligands (ARG, CLR), 5 pockets (best druggability 0.76). MolNFT v1 #148315 on GenesisL1: 3D structure, binding…
- PDB
- 6F34
- Type
- protein
- Length
- 485 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Amino acid transporter; Mgts
- UniProt
- Q5L1G5, A5A616
- Ligands
- ARG, CLR
- Pockets
- 5 · best druggability 0.76
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Amino acid transporter | protein | 458 | 72% helix, 2% strand | Q5L1G5 |
| C | Mgts | protein | 27 | 78% helix, 0% strand | A5A616 |
Ligands and binding sites
- ARG · Arginine · ligand · chains A
- CLR · Cholesterol · ligand · chains A, C
- OLC · (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate · additive · 2 copies · chains A, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 80 | 0.76 | 0.98 | 27 | ARG |
| 2 | 781 | 0.75 | 0.80 | 76 | OLC |
| 3 | 113 | 0.48 | 0.80 | 18 | empty |
| 4 | 139 | 0.44 | 0.76 | 23 | empty |
| 5 | 67 | 0.33 | 0.75 | 13 | empty |
Interfaces
1 interface between chains.
- A–C · 942 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 6F34 · Crystal structure of a bacterial cationic amino acid transporter (CAT) homologue bound to… · the same entry in another collection · chain C against C, TM-score 1.00
- A5A616 · AlphaFold monomer V2.0 prediction for small protein mgts (A5A616) · a predicted model of the same protein · chain C against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5L1G5
- Every structure of UniProt A5A616
- Elsewhere: RCSB PDB 6F34 · PDBe 6F34 · UniProt Q5L1G5 · UniProt A5A616
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