Heterodimer of the GLUN1B-GLUN2B NMDA receptor amino-terminal domains bound to allosteric inhibitor 93-6

Structure

x-ray diffraction · 3 distinct chains.

Ligands and binding sites

• HYY · N-{4-[(2S)-3-{[2-(3,4-dichlorophenyl)ethyl](propyl) amino}-2-hydroxypropoxy]phenyl}methanesulfonamide · ligand · 2 copies · chains A, B, C, D
• NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 8 copies · chains A, B, C, D
• MAN · alpha-D-mannopyranose · sugar · 2 copies
• BMA · beta-D-mannopyranose · sugar
• NA · Sodium ion · metal · 2 copies · chains A, C
• CL · Chloride ion · ion · 11 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6E7T · Heterodimer of the GluN1b-GluN2B NMDA receptor amino-terminal domains bound to allosteric… · the same entry in another collection · chain A against A, TM-score 1.00
• Q00960 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2B (Q00960) · a predicted model of the same protein · chain D against A, TM-score 0.96

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt A0A1L8F5J9
• Every structure of UniProt Q00960
• Elsewhere: RCSB PDB 6E7T · PDBe 6E7T · UniProt A0A1L8F5J9 · UniProt Q00960