D276G DNA polymerase beta substrate complex with templating cytosine and incoming fapy-dgtp analog

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• GKS · 1-[2-amino-5-(formylamino)-6-oxo-1,6-dihydropyrimidin-4-yl]-2,5-anhydro-1,3-dideoxy-6-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-D-ribo-hexitol · ligand · chains T, P, A
• NA · Sodium ion · metal · 4 copies · chains P, A, D
• CA · Calcium ion · metal · 3 copies · chains P, A
• CL · Chloride ion · ion · 3 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6DIC · D276G DNA polymerase beta substrate complex with templating cytosine and incoming… · the same entry in another collection · chain T against T, TM-score 1.00
• P06746 · AlphaFold monomer V2.0 prediction for DNA polymerase beta (P06746) · a predicted model of the same protein · chain A against A, TM-score 0.94

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P06746
• Elsewhere: RCSB PDB 6DIC · PDBe 6DIC · UniProt P06746