MolNFT v1 · #146336 · protein

Structure of lpne effector protein from legionella pneumophila (sp. philadelphia)

6DEH · Tpr repeat protein, protein-protein interaction: “Structure of lpne effector protein from legionella pneumophila (sp. philadelphia)”. X-ray diffraction, 1 ligand (NI), 2 pockets (best druggability 0.74). MolNFT v1 #146336 on…

PDB: 6DEH
Type: protein
Length: 650 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Tpr repeat protein, protein-protein interaction
UniProt: Q5ZTE0
Ligands: NI
Pockets: 2 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 70% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Tpr repeat protein, protein-protein interaction	protein	325	70% helix, 0% strand	Q5ZTE0

Ligands and binding sites

NI · Nickel (II) ion · metal · 3 copies · chains A, B
GOL · Glycerol · additive · 2 copies · chains A, B
PEG · Di(hydroxyethyl)ether · additive · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	708	0.74	0.80	71	PEG
2	88	0.32	0.73	24	empty

Interfaces

1 interface between chains.

A–B · 2987 Å² buried · 47 hydrogen bonds · protein-protein

Compared structures

6DEH · Structure of LpnE Effector Protein from Legionella pneumophila (sp. Philadelphia) · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5ZTE0
Elsewhere: RCSB PDB 6DEH · PDBe 6DEH · UniProt Q5ZTE0

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