MolNFT v1 · #145837 · protein
A V-to-F substitution in SK2 channels causes CA2+ hypersensitivity and improves locomotion in a C. elegans als model
6CZQ · Small conductance calcium-activated potassium channel…: “A V-to-F substitution in SK2 channels causes CA2+ hypersensitivity and improves locomotion in a C. elegans…”. X-ray diffraction, 2 ligands (CA, SO4), 2 pockets (best…
- PDB
- 6CZQ
- Type
- protein
- Length
- 241 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Small conductance calcium-activated potassium channel protein 2; Calmodulin-1
- UniProt
- P70604, P0DP29
- Ligands
- CA, SO4
- Pockets
- 2 · best druggability 0.37
Structure
x-ray diffraction · 2 distinct chains · 63% helix, 6% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Small conductance calcium-activated potassium channel protein 2 | protein | 95 | 73% helix, 2% strand | P70604 |
| R | Calmodulin-1 | protein | 146 | 56% helix, 8% strand | P0DP29 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 93 | 0.37 | 0.75 | 20 | empty |
| 2 | 66 | 0.35 | 0.76 | 17 | empty |
Interfaces
1 interface between chains.
- B–R · 1424 Ų buried · 18 hydrogen bonds · protein-protein
Compared structures
- 6CZQ · A V-to-F substitution in SK2 channels causes Ca2+ hypersensitivity and improves… · the same entry in another collection · chain B against B, TM-score 1.00
- P70604 · AlphaFold monomer V2.0 prediction for small conductance calcium- activated potassium… · a predicted model of the same protein · chain B against A, TM-score 0.67
- P0DP29 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP29) · a predicted model of the same protein · chain R against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70604
- Every structure of UniProt P0DP29
- Elsewhere: RCSB PDB 6CZQ · PDBe 6CZQ · UniProt P70604 · UniProt P0DP29
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